Guidance on Applying Covariate Adjustment
Relevant Regulatory Guidance
Missing Covariates
- How much missingness is too much
- Approaches and justification for missing covariates
- Preserving independence of covariates and treatment
Statistical Analysis Plans
Sample size for adjusted vs. unadjusted
Number of parameters vs. sample size
- Adjusting for sites in multi-site trial
Data-Adaptive Covariate Adjustment